Recent research has demonstrated that supplemental magnesium and B-6 can have positive effects on children's behavior. Low intraerythrocyte Mg2+ (Erc-Mg) values are associated with over-excitability and short attention spans. Supplementing with magnesium and B-6 in the ratio found in In Gear for at least two months led to an increase in Erc-Mg values and significant improvements in behavior. Magnesium and B-6 are both involved in the synthesis and uptake of neurotransmitters, including serotonin, which may account for these findings.