Our premium multivitamin -- The Big One Plus contains 2000 IU Vitamin D-3, the latest NIH recommendation. It also contains the active, phosphorylated forms of B-2 and B-6 - Riboflavin 5 Phosphate and Pyridoxal 5 Phosphate-exclusively. Another Plus -- 400 mcg of the newest generation, most bioavailable methylfolate, Quatrefolic. Combined with mixed cartenoids and methylcobalamin, these vitamin forms are newly recognized for their optimum potency and bioavailability. This superior multivitamin/mineral supplement has been scientifically formulated to provide therapeutic levels of 23 valuable nutrients to support normal breast, colon, and bone health, as well as support normal cardiovascular and immune function.